66 Sadashiv is an emotional yet humorous story of Prabhakar Shrikhande, a typical Punekar who starts an institute to spread the awareness about mastering the techniques of a new art form and is trying to gain recognition for the same.
Arjun and Supriya love each other and marry against their families' wishes. Suddenly, Arjun dies in an accident. While Supriya's boss Raghav reveals he killed Arjun. Supriya's quest to get Arjun justice forms the crux of the story.
Manmohan Desai an old man is seen coming out of the court who has legally changed his name to Mohan Desai the story takes back to 20 years when he is searching for his lost son in law Amitabh Gadgill who went missing leaving behind his pregnant wife Jaya.