In the 19th century, Anandi Joshi, a young girl, goes through several challenges to become one of India's first female physicians with the help of her husband, Gopalrao Joshi.
66 Sadashiv is an emotional yet humorous story of Prabhakar Shrikhande, a typical Punekar who starts an institute to spread the awareness about mastering the techniques of a new art form and is trying to gain recognition for the same.
The movie follows the story of cousins Anay, Shweta, Annaya and Virajas, the youngest generation of the rich and powerful Rajwade family. They each wish to follow they own dreams, but their grandfather, the head of the family, has other plans for them. Each will have to fight, argue, and question the foundations of the joint family if they want to live their dreams.